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Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

《医学前沿（英文）》 2021年 第15卷 第1期   页码 33-42 doi: 10.1007/s11684-019-0735-3

摘要： Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitors (ICIs) are the most successful agents approved for multiple advanced malignancies. However, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related adverse events (irAEs) in almost all organs or systems. Up to 90% of patients who received ICIs combination therapy experienced irAEs, of which majority were low-grade toxicity. Cytotoxic lymphocyte antigen-4 and programmed cell death protein-1/programmed cell death ligand 1 inhibitors usually display distinct features of irAEs. In this review, the mechanisms of action of ICIs and how they may cause irAEs are described. Some unsolved challenges, however really engrossing issues, such as the association between irAEs and cancer treatment response, tumor response to irAEs therapy, and ICIs in challenging populations, are comprehensively summarized.

关键词： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

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surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverserespiratory events in post anesthesia care unit

null

《医学前沿（英文）》 2018年 第12卷 第2期   页码 189-195 doi: 10.1007/s11684-017-0533-8

摘要：

Obstructive sleep apnea syndrome (OSAS) increases the risk of post-surgery complications. This study uses Berlin Questionnaire (BQ) to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit (PACU). Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others (6.8% vs. 0.9%, <0.001). They also stayed longer than others in the PACU (95±28 min vs. 62±19 min, <0.001). Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.

关键词： obstructive sleep apnea     Berlin Questionnaire     Chinese surgical patients     adverse respiratory event    

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Multi-target combinatory strategy to overcome tumor immune escape

《医学前沿（英文）》 2022年 第16卷 第2期   页码 208-215 doi: 10.1007/s11684-022-0922-5

摘要： Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancer treatment. Many immune checkpoints were identified in the last decade since ipilimumab, which is the first immune checkpoint inhibitor to cytotoxic T-lymphocyte associated protein 4, had been approved by the US Food and Drug Administration (FDA) for the treatment of unresectable or metastatic melanoma in 2011. The use of several antibody drugs that target PD1/PD-L1 for various cancer treatments has been approved by the FDA. However, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers. Approximately 80% of patients do not respond appropriately because of primary or acquired therapeutic resistance. Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immune checkpoint inhibitors becomes a new option when monotherapy could not receive a good response. In this work, the author focuses on the combination therapy of multiple immune checkpoints (does not include targeted therapy of oncogenes or chemotherapy), introduces the current progression of multiple immune checkpoints and their related inhibitors, and discusses the advantages of combination therapy, as well as the risk of immune-related adverse events.

关键词： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 20-31 doi: 10.1007/s11684-016-0493-4

摘要：

To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before the results of imaging techniques are obtained. While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provide relevant specific biomarkers because of its close contact with the tumor. Herein, the current progress in the relationship between gastrointestinal fluid analyses and GC is systematically and comprehensively reviewed. The detection of gastric juice pH, fluorescence spectrum, cytology, Helicobacter pylori-associated markers, nitrosamines, conventional tumor markers, amino acids, proteomics, microRNAs, long noncoding RNAs, protein-coding genes, vitamin C, etc., and combination tests of different category markers could provide important diagnostic and prognostic clues for gastrointestinal diseases. Particularly, early GC may be efficiently screened using gastric juice. Gastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such as pancreatic leakage, fistula, and abscess. Gastric fluid markers should be further studied to reveal the early predicators of malignancy and complications. The methods for obtaining the samples of gastrointestinal juice with minimum incision should also be comprehensively investigated.

关键词： gastrointestinal fluid     gastric carcinoma     biomarker     diagnosis     prognosis     gastrectomy     adverse events    

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Smoothing ramp events in wind farm based on dynamic programming in energy internet

Jiang LI, Guodong LIU, Shuo ZHANG

《能源前沿（英文）》 2018年 第12卷 第4期   页码 550-559 doi: 10.1007/s11708-018-0593-8

摘要：

The concept of energy internet has been gradually accepted, which can optimize the consumption of fossil energy and renewable energy resources. When wind power is integrated into the main grid, ramp events caused by stochastic wind power fluctuation may threaten the security of power systems. This paper proposes a dynamic programming method in smoothing ramp events. First, the energy internet model of wind power, pumped storage power station, and gas power station is established. Then, the optimization problem in the energy internet is transformed into a multi-stage dynamic programming problem, and the dynamic programming method proposed is applied to solve the optimization problem. Finally, the evaluation functions are introduced to evaluate pollutant emissions. The results show that the dynamic programming method proposed is effective for smoothing wind power and reducing ramp events in energy internet.

关键词： energy internet     wind power     ramp events     dynamic programming    

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The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

《能源前沿（英文）》 2023年 第17卷 第1期   页码 1-4 doi: 10.1007/s11708-023-0869-5

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逆压梯度下近壁湍流的喷射和扫掠

张强,陆利蓬

《中国工程科学》 2003年 第5卷 第11期   页码 47-50

摘要：

采用Fourier谱展开和紧致有限差分格式，选用两组共振三波为相干结构的初值，计算了其在零压和逆压梯度作用下的演化。对演化后期流场的2，4象限的运动进行了详细的分析。结果发现，在逆压梯度下，扫掠对雷诺应力的贡献要强于喷射。无论是在零压梯度还是逆压梯度下，uv和u2在法向的输运主要是靠Q2和Q4这两种运动来完成的。零压梯度下喷射部分对输运的贡献大于扫掠的部分。而在逆压梯度下喷射部分对输运的贡献明显减少，扫掠的作用要强于喷射。

关键词： 相干结构     湍流边界层     逆压梯度     直接数值模拟    

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design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

《医学前沿（英文）》 2019年 第13卷 第2期   页码 277-284 doi: 10.1007/s11684-018-0630-3

摘要： The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa values of nitrogen atoms in pyrimidine rings has been previously suggested by our group. In this work, we proposed that new PPIs should have the following features: (1) number of ring II= number of ring I+ 1; (2) preferably five, six, or seven-membered heteroatomic ring for stability; and (3) 1

关键词： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

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The effects of festivals and special events on city image design

LIU Yuan, CHEN Chong

《结构与土木工程前沿（英文）》 2007年 第1卷 第2期   页码 255-259 doi: 10.1007/s11709-007-0032-0

摘要： City marketing provides a good vehicle to strengthen a city in competition. On the analysis of the important roles of events and city image in the context of city marketing, this paper suggests that holding festivals or special events is an effective approach to enhance city marketing. The positive impacts of festivals and special events, such as the identification of city image, the promotion of the transmission of city image, and the reversal of the negative image of the city, are discussed. The negative impacts of festivals and special events are also talked about. The unique image of the city could be identified by the City Mind Identity, the City Visual Identity and the City Behavior Identity concerned with festivals and special events.

关键词： Visual Identity     reversal     transmission     marketing     Behavior Identity    

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Characterization of bacterial communities during persistent fog and haze events in the Qingdao coastal

《环境科学与工程前沿（英文）》 2021年 第15卷 第3期 doi: 10.1007/s11783-020-1334-x

摘要：

• Light haze had little effect on bacterial communities.

关键词： Bacterial community     Persistent fog and haze     Particle size    

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Key uncertainty events impacting on the completion time of highway construction projects

Alireza MOGHAYEDI, Abimbola WINDAPO

《工程管理前沿（英文）》 2019年 第6卷 第2期   页码 275-298 doi: 10.1007/s42524-019-0022-7

摘要： This paper examines the uncertainty events encountered in the process of constructing highways, and evaluates their impact on construction time, on highway projects in South Africa. The rationale for this examination stems from the view held by scholars that the construction of highways is a complex process, taking place in changing environments and often beset by uncertainties; and that there is a lack of appropriate evaluation of these uncertainty events occurring during the construction process. The research made use of a review of extant literature in the area of uncertainty management, and modeling in infrastructure projects, to guide the direction of the study. The inquiry process consisted of brainstorming by highway experts and interviewing them to identify the uncertainty factors that impact construction time. An uncertainty matrix for South African highway projects was developed, using a quantitative model and descriptive statistics. It emerged from the study that the uncertainty events affecting the construction time of highway projects are distributed across economic, environmental, financial, legal, political, social and technical factors. Also, it was found that each factor might account for several uncertainty events which impact on construction time differently, through a combination of the uncertainty events of the individual construction activities. Based on the obtained data, an Adaptive Neuro Fuzzy Inference System (ANFIS) has been developed, as a simple, reliable and accurate advanced machine learning technique to assess the impact of uncertainty events on the completion time of highway construction projects. To validate the ANFIS model, the Stepwise Regression (SR) models have been designed and their results are compared with the results of the ANFIS. Based on the predicted impact size of uncertainty events on the time of highway projects, it can be concluded that construction time on South African highway projects is significantly related to the social and technical uncertainties factors.

关键词： ANFIS     construction time     impact assessment     highway project     South Africa     uncertainty    

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浅谈五种宫内节育器不良反应分析

李华洁

《中国工程科学》 2015年 第17卷 第6期   页码 28-30

摘要：

通过观察放置宫内节育器（IUD），爱母环（MCU）、母体乐（MCU375）、宫形环（GCU300）、TCU220C和吉妮环术后不良反应情况，为育龄妇女知情选择IUD提供参考依据。将671例自愿采取放置宫内节育器避孕而无禁忌症的妇女随机分成五组，分别放置A组MCU，B组MCU375，C组GCU300，D组TCU220C，E组吉妮环五种IDU，随访两年，对其术后月经量增多，经期延长，阴道不规则流血，疼痛，脱环，带器妊娠，白带增多情况进行比较。MCU的不良反应较为严重，MCU375和GCU300的不良反应次之，TCU220C和吉妮环不良反应最轻。GCU300的脱环率最高，TCU220C、MCU和MCU375、吉妮环的脱环率都比较低；带器妊娠MCU和GCU300最高，MCU375、TCU220C和吉妮环均低。临床应根据受器者的具体情况选择适当的IUD，提高育龄妇女对避孕措施的满意程度。

关键词： 节育环；不良反应；吉妮环    

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基于矿物异常分析的隧道内不良地质识别方法及案例分析 Article

许振浩, 余腾飞, 林鹏, 李术才

《工程（英文）》 2023年 第27卷 第8期   页码 150-160 doi: 10.1016/j.eng.2022.09.013

摘要： 本研究提出了一种基于矿物异常分析的隧道不良地质识别方法（adverse geology identification through mineral anomaly analysis, AGIMAA），

关键词： 矿物异常     不良地质     断层     蚀变     异常阈值    

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evolution of charged and neutral nanoparticle concentrations during atmospheric new particle formation events

E. Rohan Jayaratne, Buddhi Pushpawela, Lidia Morawska

《环境科学与工程前沿（英文）》 2016年 第10卷 第5期 doi: 10.1007/s11783-016-0862-x

摘要： Over 100 new particle formation events were studied. In 50 events, charged and neutral particles were not formed at the same time. In 42 of these events the charged particles formed before the neutral particles. Their subsequent growth rates were not determined by the particle charge. The result suggests that ion induced nucleation plays a role in particle formation. Time series of nanoparticle number concentration during new particle formation (NPF) events in the urban environment of Brisbane, Australia, showed that the formation of charged particles often occurred before that of neutral particles. We monitored 241 days during the calendar year 2012 over which NPF events were observed on 108 days. We studied the times at which the charged and neutral particle concentrations in the size range 1.8–3.2 nm reached their peak values and found that they were clearly different in 50 events with the peak neutral particle concentration lagging behind the charged particle concentration during 42 of these events with a mean time lag of 24±12 min. While the charged particles were more likely to form before the neutral particles, once formed, the growth rate of the particles did not depend on their charge. While ion-induced nucleation is not the dominant mechanism of NPF in the atmosphere, our observations suggest that the presence of ions in the atmosphere plays a role that cannot be ignored.

关键词： Charged particles     Cluster ions     Secondary particles     Environmental pollution    

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Key features of new particle formation events at background sites in China and their influence on cloud

Xiaojing SHEN,Junying SUN,Xiaoye ZHANG,Yangmei ZHANG,Lu ZHANG,Ruxia FAN

《环境科学与工程前沿（英文）》 2016年 第10卷 第5期 doi: 10.1007/s11783-016-0833-2

摘要： New particle formation (NPF) event at multi rural sites in China Identifying the characteristics of NPF event Comparing NPF event between clean and polluted conditions Quantifying contribution to the cloud condensation nuclei Implication of climate and air quality Long-term continuous measurements of particle number size distributions with mobility diameter sizes ranging from 3 to 800 nm were performed to study new particle formation (NPF) events at Shangdianzi (SDZ), Mt. Tai (TS), and Lin’an (LAN) stations representing the background atmospheric conditions in the North China Plain (NCP), Central East China (CEC), and Yangtze River Delta (YRD) regions, respectively. The mean formation rate of 3-nm particles was 6.3, 3.7, and 5.8 cm ·s , and the mean particle growth rate was 3.6, 6.0, and 6.2 nm·h at SDZ, TS, and LAN, respectively. The NPF event characteristics at the three sites indicate that there may be a stronger source of low volatile vapors and higher condensational sink of pre-existing particles in the YRD region. The formation rate of NPF events at these sites, as well as the condensation sink, is approximately 10 times higher than some results reported at rural/urban sites in western countries. However, the growth rates appear to be 1–2 times higher. Approximately 12%–17% of all NPF events with nucleated particles grow to a climate-relevant size (>50 nm). These kinds of NPF events were normally observed with higher growth rate than the other NPF cases. Generally, the cloud condensation nuclei (CCN) number concentration can be enhanced by approximately a factor of 2–6 on these event days. The mean value of the enhancement factor is lowest at LAN (2–3) and highest at SDZ (~4). NPF events have also been found to have greater impact on CCN production in China at the regional scale than in the other background sites worldwide.

关键词： New particle formation     Regional background     Cloud condensation nuclei     Growth rate     Formation rate    

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标题 作者 时间 类型 操作

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

期刊论文

surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverserespiratory events in post anesthesia care unit

null

期刊论文

Multi-target combinatory strategy to overcome tumor immune escape

期刊论文

Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination

null

期刊论文

Smoothing ramp events in wind farm based on dynamic programming in energy internet

Jiang LI, Guodong LIU, Shuo ZHANG

期刊论文

The most influential “Top 10 Events” in carbon neutrality and climate change in 2022

期刊论文

逆压梯度下近壁湍流的喷射和扫掠

张强,陆利蓬

期刊论文

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

期刊论文

The effects of festivals and special events on city image design

LIU Yuan, CHEN Chong

期刊论文

Characterization of bacterial communities during persistent fog and haze events in the Qingdao coastal

期刊论文

Key uncertainty events impacting on the completion time of highway construction projects

Alireza MOGHAYEDI, Abimbola WINDAPO

期刊论文

浅谈五种宫内节育器不良反应分析

李华洁

期刊论文

基于矿物异常分析的隧道内不良地质识别方法及案例分析

许振浩, 余腾飞, 林鹏, 李术才

期刊论文

evolution of charged and neutral nanoparticle concentrations during atmospheric new particle formation events

E. Rohan Jayaratne, Buddhi Pushpawela, Lidia Morawska

期刊论文

Key features of new particle formation events at background sites in China and their influence on cloud

Xiaojing SHEN,Junying SUN,Xiaoye ZHANG,Yangmei ZHANG,Lu ZHANG,Ruxia FAN

期刊论文